Genomics of Exertional Related Events (EREs)
We invite African-American SCT positive men and women and their family members, with or without a history of ERE, to participate. Volunteers must be between the ages of 18 and 80.
Participants will be required to do the following:
- Sign the Informed Consent Document (ICD) and HIPAA authorization form to grant access to medical information related to SCT and ERE
- Fill out a questionnaire, including a brief medical history
- Give no more than 25 mL (less than 2 tablespoons) of bloodUpon completion of all study requirements, participants will be compensated with a $25 gift card.
Our Goals:
Collect scientific data needed to guide more evidence-based and prudent treatment and policy decisions that impact the Sickle Cell Trait (SCT) population in both civilian and military sectors.
Our Plans:
Enroll African American men and women between ages 18-80 who have SCT:
300 SCT carriers who have had Exertional- Related Events (EREs):
- Exertional Rhabdomyolysis
- Exertional Heat Stroke
- Exertional Collapse
150 SCT carriers who have never had EREs despite their rigorous exercise regimen
Enroll 150 immediate family members of these SCT carriers, with and without ERE
Identify and compare genetic variants between SCT carriers with ERE and without EREI
How you can contribute:
Participate by donating blood
Completing a questionnaire
Providing brief medical history
What we will do:
Extract genetic material
Screen whole genome
What we expect to find:
Genetic variants associated with EREs in SCT carriers that will help us develop markers to determine who may be susceptible to EREs prior to an event.