Exertion Related Events (EREs) such as exercise-related muscle damage, heat stroke, and collapse have been observed in individuals with Sickle Cell Trait (SCT). The Consortium of Health and Military Performance (CHAMP), Uniformed Services University (USU) is conducting a study to better understand the association between SCT and EREs. This study will search for genetic markers of EREs in individuals with SCT.
We invite African-American SCT positive men and women and their family members, with or without a history of ERE, to participate.
Volunteers must be between the ages of 18 and 80.
Participants will be required to do the following:
- Sign the Informed Consent Document (ICD) and HIPAA authorization form to grant access to medical information related to SCT and ERE
- Fill out a questionnaire, including a brief medical history
- Give no more than 25 mL (less than 2 tablespoons) of bloodUpon completion of all study requirements, participants will be compensated with a $25 gift card.
Collect scientific data needed to guide more evidence-based and prudent treatment and policy decisions that impact the Sickle Cell Trait (SCT) population in both civilian and military sectors.
Enroll African American men and women between ages 18-80 who have SCT:
300 SCT carriers who have had Exertional- Related Events (EREs):
- Exertional Rhabdomyolysis
- Exertional Heat Stroke
- Exertional Collapse
150 SCT carriers who have never had EREs despite their rigorous exercise regimen
Enroll 150 immediate family members of these SCT carriers, with and without ERE
Identify and compare genetic variants between SCT carriers with ERE and without EREI